Some 400 Russian troops have been killed over the past 24 hours, the ministry said in a statement.
The Ukrainian forces have also destroyed 202 Russian aircraft, 167 helicopters, 441 unmanned aerial vehicles, 1,251 tanks, 3,043 armored vehicles, and 586 cannons since Feb. 24, according to the latest update.
A total of 199 Russian multiple rocket launcher systems, 2,137 vehicles, 102 cruise missiles, 91 anti-aircraft systems, and 13 boats have also been destroyed, the statement added.
The Russian forces suffered the "greatest losses" over the past day in the eastern Slovyansk, central Kryvyi Rih and southeastern Zaporizhzhia areas, it said.
The Russian Defense Ministry, in a statement on March 25, confirmed that 1,351 Russian troops were killed in Ukraine.